covid: Covid vax protection wane over time, boosters important: Pfizer, Moderna


NEW YORK: US Drug Manufacturers Pfizer and Moderna, in different studies, have claimed that the protection of their mRNA vaccine against Covid-19 can last only about six months, or a little longer, making a strong case for booster injections, ignoring calls against it. by a number of scientists.
On Wednesday, Moderna in a new analysis of its phase three study showed that a low dose of its vaccine lasts only six months.
The findings showed that the incidence of advance COVID-19 the cases were less frequent in the participants who were inoculated more recently, indicating that the immunity of previously vaccinated people had begun to wane.
Of the 11,431 people vaccinated between December and March, 88 were identified as breakthrough cases compared to 162 breakthrough cases of the 14,746 trial participants vaccinated between July and October last year, the company said in a statement.
“The increased risk of serious infections in participants who were vaccinated last year compared to the most recent ones illustrates the impact of waning immunity and supports the need for a booster to maintain high levels of protection,” said Moderna CEO. Stephane bancel it said in a statement.
Similarly, on Wednesday, Pfizer cited data from Israel to present a case to the US Food and Drug Administration for thrusters. The US pharmaceutical giant argued that a third dose of the Covid vaccine six months after a second injection restores protection against infection to 95%, CNBC reported.
While the effectiveness of the mRNA vaccine diminishes over time, a booster injection was shown to elicit an immune response similar to the protection generated after a second dose, Pfizer said in a 52-page submission submitted to the US FDA. USA
While many countries such as Israel, the United Arab Emirates, Russia, France, Germany and Italy have proceeded with the booster doses, many scientists have called against the third Covid vaccine.
Last week, AstraZeneca CEO Pascal Soriot wrote in the Telegraph that not everyone may need a third dose of Covid-19 vaccines.
He stated that the decision to prick the entire population should be based on “real-world clinical efficacy data, not simply antibody measurements.”
In a recent review published in The Lancet, an international group of scientists argued that the efficacy of the severe Covid vaccine is so high, even for the Delta variant, that booster doses for the general population are “not appropriate” in this stage of the pandemic.
They reiterated the concern expressed by the World Health Organization (WHO) on vaccine inequality in rich countries. Meanwhile, the WHO has called for an extension of a global moratorium on Covid-19 booster doses, with the aim of allowing all countries to vaccinate at least 40% of their population.

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