The five-time Ballon d’Or winner, who left United to join Real Madrid in 2009, he returned to the club in a surprise transfer from Juventus just before the transfer deadline.
United manager Ole Gunnar Solskjaer said the 36-year-old forward would feature “at some point” in the kickoff at 1400 GMT.
Since joining United, Ronaldo has broken the all-time international goal record with his 110th goal for Portugal in a World Cup qualifying victory against the Republic of Ireland.
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Having been suspended for the next game against Azerbaijan for removing his shirt in celebration, he traveled to England and has been training with his new teammates for the past few days.
It remains to be seen whether Ronaldo will start or come off the bench.
“He has had a good preseason with Juventus, he has played for the national team, he has had a good week with us here,” Solskjaer said.
“He will definitely be on the field at some point, that’s for sure.”
Ronaldo won three Premier League titles and the Champions League for six trophy-laden years with United, before shining with Real and Juventus.
It seemed that United would miss out on reuniting with their former star when Manchester City moved in to sign him.
But Ronaldo has said that his relationship with the former United manager Alex Ferguson played a key role in convincing him to return to Old Trafford, calling the move “a dream come true”.
Solskjaer, who played with Ronaldo during his first time at the club, said: “Of course, we have followed his career from afar since he left here and I think everyone is very happy to have him back.
“He can speak for himself, but it looks like he’s happy to be back too.
“The mood has been very good, he has worked well and we are looking forward to Saturday, of course.”
Before Ronaldo’s unexpected acquisition, Solskjaer had already beefed up his squad with plummets from 21-year-old English striker Jadon Sancho and World Cup-winning French defender. Raphael varane.
United are expected to challenge champion Manchester City for the title after such a productive transfer window.
Solskjaer believes that Ronaldo will add a higher level of quality to the team, both physically and mentally, as they try to secure a first trophy of the Norwegian’s reign.
“We have grown as a group in recent years. The determination, the desire, the focus has improved over time and little by little,” he said.
“Even like bringing in Raphael (Varane), he has come with a winner mentality, an incredible approach.
“So, of course, Cristiano comes in too and there is no place to hide when you have winners like them. You can’t go to train and give 95 percent or not be focused.”